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  1. Dermatology: Acral Melanoma, Dorsal

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    Description: A malignant neoplasm derived from cells that are capable of forming melanin affecting distal portions of limbs and the head. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
    Keywords: melanoma, skin, acral, finger, nail, fingernail, malignant melanoma, fingertip

  2. Dermatology: Acral Melanoma, Palmar

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    Description: A malignant neoplasm derived from cells that are capable of forming melanin affecting distal portions of limbs and the head. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
    Keywords: malignant melanoma, fingertip, melanoma, skin, finger, fingernail, nail, acral

  3. Dermatology: Acral Melanoma, Lateral

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    Description: A malignant neoplasm derived from cells that are capable of forming melanin affecting distal portions of limbs and the head. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
    Keywords: fingertip, melanoma, acral, nail, fingernail, finger, skin, malignant melanoma

  4. Chronic Bullous Disease Of Childhood

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    Description: Rare autoimmune skin condition resulting in clusters of blisters developing in rings, often on the face or genitals. Also known as linear IgA disease. This case is shown on a child in Kenya. Note kwashiorkor body habitus and leukonychia in photo.
    Keywords: Skin Diseases, Linear IgA Bullous Dermatosis, Vancomycin, Immunoglobulin A, severe protein–energy malnutrition, Autoimmune Diseases, Kwashiorkor, Immunoglobulin G, Basement Membrane

  5. Chronic Bullous Disease Of Childhood

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    Description: Rare autoimmune skin condition resulting in clusters of blisters developing in rings, often on the face or genitals. Also known as linear IgA disease. This case is shown on a child in Kenya.
    Keywords: Basement Membrane, Linear IgA Bullous Dermatosis, Skin Diseases, Autoimmune Diseases, Immunoglobulin A, severe protein–energy malnutrition, Immunoglobulin G, Vancomycin

  6. Dermatology: Xanthelasma

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    Description: Stomach-xanthelasma A papule, nodule, or plaque in the skin due to lipid deposits; it is usually yellow, but may be brown, reddish, or cream colored. Microscopically, the lesions show light cells with foamy protoplasm (foam cells). Xanthomas range in size from tiny pinheads to large nodules, and the shape may be round, flat, or irregular. They are often found around the eyes, the joints, the neck or the palms, or over tendons. Often these lipid deposits are not limited to the skin but are found throughout the body in bones, the heart, blood vessels, liver, and other organs.
    Keywords: Plaque, lipid deposits, skin, nodule

  7. Dermatology: Warfarin-induced Skin Necrosis, Fatal, Breast

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    Description: Fatal skin necrosis at breast, induced by heparin. Skin necrosis is the pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage; earliest irreversible changesare mitochondrial, consisting of swelling and granular calcium deposits seen by electron microscopy; most frequent visible alterationsare nuclear: pyknosis, shrunken and abnormally dark basophilic staining; karyolysis, swollen and abnormally pale basophilic staining;or karyorrhexis, rupture, and fragmentation of the nucleus. After such changes, the outlines of individual cells are indistinct, andaffected cells may merge, sometimes forming a focus of coarsely granular, amorphous, or hyaline material.
    Keywords: skin, Cell death, Pathological Conditions, mitochondrial swelling, cell lysis, Pathologic Processes, Signs and Symptoms

  8. Dermatology: Skin, Warfarin-induced Skin Necrosis, Fatal

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    Description: Fatal skin necrosis, induced by heparin. Skin necrosis is the pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage; earliest irreversible changesare mitochondrial, consisting of swelling and granular calcium deposits seen by electron microscopy; most frequent visible alterationsare nuclear: pyknosis, shrunken and abnormally dark basophilic staining; karyolysis, swollen and abnormally pale basophilic staining;or karyorrhexis, rupture, and fragmentation of the nucleus. After such changes, the outlines of individual cells are indistinct, andaffected cells may merge, sometimes forming a focus of coarsely granular, amorphous, or hyaline material
    Keywords: mitochondrial swelling, Signs and Symptoms, Pathological Conditions, skin, Cell death, Pathologic Processes, cell lysis

  9. Dermatology: Angiosarcoma, Leg

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    Description: A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed) This example occurred on the leg, and was taken after three weeks of growth
    Keywords: neoplasm, leg, cell replication, death, fatality, sarcoma, blood

  10. Dermatology: Angiosarcoma, Leg

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    Description: A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed) This example occurred on the leg, and was fatal to the patient.
    Keywords: leg, blood, neoplasm, cell replication, death, sarcoma, fatality