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  1. Dermatology: Warfarin-induced Skin Necrosis, Fatal, Breast

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    Description: Fatal skin necrosis at breast, induced by heparin. Skin necrosis is the pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage; earliest irreversible changesare mitochondrial, consisting of swelling and granular calcium deposits seen by electron microscopy; most frequent visible alterationsare nuclear: pyknosis, shrunken and abnormally dark basophilic staining; karyolysis, swollen and abnormally pale basophilic staining;or karyorrhexis, rupture, and fragmentation of the nucleus. After such changes, the outlines of individual cells are indistinct, andaffected cells may merge, sometimes forming a focus of coarsely granular, amorphous, or hyaline material.
    Keywords: skin, Cell death, Pathological Conditions, mitochondrial swelling, cell lysis, Pathologic Processes, Signs and Symptoms

  2. Dermatology: Skin, Warfarin-induced Skin Necrosis, Fatal

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    Description: Fatal skin necrosis, induced by heparin. Skin necrosis is the pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage; earliest irreversible changesare mitochondrial, consisting of swelling and granular calcium deposits seen by electron microscopy; most frequent visible alterationsare nuclear: pyknosis, shrunken and abnormally dark basophilic staining; karyolysis, swollen and abnormally pale basophilic staining;or karyorrhexis, rupture, and fragmentation of the nucleus. After such changes, the outlines of individual cells are indistinct, andaffected cells may merge, sometimes forming a focus of coarsely granular, amorphous, or hyaline material
    Keywords: mitochondrial swelling, Signs and Symptoms, Pathological Conditions, skin, Cell death, Pathologic Processes, cell lysis

  3. Cutaneous Vasculitis With Skin Necrosis, SLE Patient, Image 2

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    Description: Vasculitis (plural: vasculitides) is a group of disorders that destroy blood vessels by inflammation. Both arteries and veins are affected. Lymphangitis is sometimes considered a type of vasculitis.[3] Vasculitis is primarily due to leukocyte migration and resultant damage.
    Keywords: Cell Physiological Phenomena, Cell Physiological Processes, blood vessels, Vascular Diseases, Inflammation

  4. Cutaneous Vasculitis With Skin Necrosis, SLE Patient, Image 3

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    Description: Vasculitis (plural: vasculitides) is a group of disorders that destroy blood vessels by inflammation. Both arteries and veins are affected. Lymphangitis is sometimes considered a type of vasculitis.[3] Vasculitis is primarily due to leukocyte migration and resultant damage.
    Keywords: blood vessels, Cell Physiological Processes, Vascular Diseases, Inflammation, Cell Physiological Phenomena

  5. Cutaneous Vasculitis With Skin Necrosis, SLE Patient, Image 1

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    Description: Vasculitis (plural: vasculitides) is a group of disorders that destroy blood vessels by inflammation. Both arteries and veins are affected. Lymphangitis is sometimes considered a type of vasculitis.[3] Vasculitis is primarily due to leukocyte migration and resultant damage.
    Keywords: blood vessels, Cell Physiological Processes, Cell Physiological Phenomena, Inflammation, Vascular Diseases