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- Title:
- Dermatology: Warfarin-induced Skin Necrosis, Fatal, Breast
- Description:
- Fatal skin necrosis at breast, induced by heparin. Skin necrosis is the pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage; earliest irreversible changesare mitochondrial, consisting of swelling and granular calcium deposits seen by electron microscopy; most frequent visible alterationsare nuclear: pyknosis, shrunken and abnormally dark basophilic staining; karyolysis, swollen and abnormally pale basophilic staining;or karyorrhexis, rupture, and fragmentation of the nucleus. After such changes, the outlines of individual cells are indistinct, andaffected cells may merge, sometimes forming a focus of coarsely granular, amorphous, or hyaline material.
- Keyword:
- skin, Cell death, Pathological Conditions, mitochondrial swelling, cell lysis, Pathologic Processes, Signs and Symptoms
- Subject:
- Breast, Necrosis, Dermatology
- Creator:
- Metropolitan Hospital Center, Kathryn Russel, MD
- Publisher:
- i-Human Patients
- Language:
- English
- Copyright Holder:
- Metropolitan Hospital Center
- Rights:
- http://www.i-human.com/service-agreement-print
- Resource Type:
- Photograph
