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  1. Dermatology: Xanthelasma

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    Description: Stomach-xanthelasma A papule, nodule, or plaque in the skin due to lipid deposits; it is usually yellow, but may be brown, reddish, or cream colored. Microscopically, the lesions show light cells with foamy protoplasm (foam cells). Xanthomas range in size from tiny pinheads to large nodules, and the shape may be round, flat, or irregular. They are often found around the eyes, the joints, the neck or the palms, or over tendons. Often these lipid deposits are not limited to the skin but are found throughout the body in bones, the heart, blood vessels, liver, and other organs.
    Keywords: Plaque, lipid deposits, skin, nodule

  2. Dermatology: Warfarin-induced Skin Necrosis, Fatal, Breast

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    Description: Fatal skin necrosis at breast, induced by heparin. Skin necrosis is the pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage; earliest irreversible changesare mitochondrial, consisting of swelling and granular calcium deposits seen by electron microscopy; most frequent visible alterationsare nuclear: pyknosis, shrunken and abnormally dark basophilic staining; karyolysis, swollen and abnormally pale basophilic staining;or karyorrhexis, rupture, and fragmentation of the nucleus. After such changes, the outlines of individual cells are indistinct, andaffected cells may merge, sometimes forming a focus of coarsely granular, amorphous, or hyaline material.
    Keywords: skin, Cell death, Pathological Conditions, mitochondrial swelling, cell lysis, Pathologic Processes, Signs and Symptoms

  3. Dermatology: Skin, Warfarin-induced Skin Necrosis, Fatal

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    Description: Fatal skin necrosis, induced by heparin. Skin necrosis is the pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage; earliest irreversible changesare mitochondrial, consisting of swelling and granular calcium deposits seen by electron microscopy; most frequent visible alterationsare nuclear: pyknosis, shrunken and abnormally dark basophilic staining; karyolysis, swollen and abnormally pale basophilic staining;or karyorrhexis, rupture, and fragmentation of the nucleus. After such changes, the outlines of individual cells are indistinct, andaffected cells may merge, sometimes forming a focus of coarsely granular, amorphous, or hyaline material
    Keywords: mitochondrial swelling, Signs and Symptoms, Pathological Conditions, skin, Cell death, Pathologic Processes, cell lysis

  4. Dermatology: Angiosarcoma, Leg

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    Description: A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed) This example occurred on the leg, and was taken after three weeks of growth
    Keywords: neoplasm, leg, cell replication, death, fatality, sarcoma, blood

  5. Dermatology: Angiosarcoma, Leg

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    Description: A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed) This example occurred on the leg, and was fatal to the patient.
    Keywords: leg, blood, neoplasm, cell replication, death, sarcoma, fatality

  6. Dermatology: Angiosarcoma, Leg

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    Description: A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed) This example occurred on the leg, and was fatal to the patient.
    Keywords: neoplasm, leg, death, blood, cell replication, fatality, sarcoma

  7. Dermatology: Vitiligo Vulgaris

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    Description: Vitiligo - depigmented patches over lips Vitiligo is a common, often inherited disorder characterized by areas of well-defined, milky white skin. People with vitiligo may have eye abnormalities and also have a higher incidence of thyroid disease, diabetes mellitus, and pernicious anemia. Vitiligo affects about 1-2% of the world's population. It is more easily observed in sun-exposed areas of the body and in darker skin types, but it affects any area of the body and all races. Vitiligo seems to affect men and women equally, although women more frequently seek treatment for the disorder. Vitiligo may appear as one or two well-defined white patches or it may appear over large portions of the body. Typical sites for generalized vitiligo are areas surrounding body openings, bony areas, fingers, and toes. It can begin at any age but about 50% of the time it starts before the age of 20.
    Keywords: skin disorder, macular depigmentation, depigmentation, Vitiligo vulgaris, non-segmental vitiligo, bilateral vitiligo, generalized vitiligo

  8. Dermatology: Xanthoma

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    Description: Xanthoma post-op after excision A papule, nodule, or plaque in the skin due to lipid deposits; it is usually yellow, but may be brown, reddish, or cream colored. Microscopically, the lesions show light cells with foamy protoplasm (foam cells). Xanthomas range in size from tiny pinheads to large nodules, and the shape may be round, flat, or irregular. They are often found around the eyes, the joints, the neck or the palms, or over tendons. Often these lipid deposits are not limited to the skin but are found throughout the body in bones, the heart, blood vessels, liver, and other organs.
    Keywords: Plaque, lipid deposits, skin, nodule

  9. Dermatology: Vitiligo Vulgaris

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    Description: Vitiligo vulgaris treated by punch grafting (seven days post-op) Vitiligo is a common, often inherited disorder characterized by areas of well-defined, milky white skin. People with vitiligo may have eye abnormalities and also have a higher incidence of thyroid disease, diabetes mellitus, and pernicious anemia. Vitiligo affects about 1-2% of the world's population. It is more easily observed in sun-exposed areas of the body and in darker skin types, but it affects any area of the body and all races. Vitiligo seems to affect men and women equally, although women more frequently seek treatment for the disorder. Vitiligo may appear as one or two well-defined white patches or it may appear over large portions of the body. Typical sites for generalized vitiligo are areas surrounding body openings, bony areas, fingers, and toes. It can begin at any age but about 50% of the time it starts before the age of 20.
    Keywords: generalized vitiligo, bilateral vitiligo, non-segmental vitiligo, macular depigmentation, depigmentation, Vitiligo vulgaris, skin disorder

  10. Dermatology: Vitiligo Vulgaris

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    Description: Vitiligo vulgaris treated by punch grafting (immediate post-op) Vitiligo is a common, often inherited disorder characterized by areas of well-defined, milky white skin. People with vitiligo may have eye abnormalities and also have a higher incidence of thyroid disease, diabetes mellitus, and pernicious anemia. Vitiligo affects about 1-2% of the world's population. It is more easily observed in sun-exposed areas of the body and in darker skin types, but it affects any area of the body and all races. Vitiligo seems to affect men and women equally, although women more frequently seek treatment for the disorder. Vitiligo may appear as one or two well-defined white patches or it may appear over large portions of the body. Typical sites for generalized vitiligo are areas surrounding body openings, bony areas, fingers, and toes. It can begin at any age but about 50% of the time it starts before the age of 20.
    Keywords: non-segmental vitiligo, macular depigmentation, bilateral vitiligo, Vitiligo vulgaris, skin disorder, depigmentation, generalized vitiligo